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Publication Detail

Title: Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years.

Authors: Vuong, Ann M; Yolton, Kimberly; Xie, Changchun; Webster, Glenys M; Sjödin, Andreas; Braun, Joseph M; Dietrich, Kim N; Lanphear, Bruce P; Chen, Aimin

Published In Environ Res, (2017 10)

Abstract: Prenatal polybrominated diphenyl ether (PBDE) exposure has been associated with decrements in IQ and increased attention deficit/hyperactivity disorder related behaviors in children; however, data are limited for the role of postnatal exposures.We investigated the association between a series of childhood PBDE concentrations and Full-Scale Intelligence Quotient (FSIQ) and externalizing problems at 8 years.We used data from 208 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort. Child serum PBDEs were measured at 1, 2, 3, 5, and 8 years; missing serum PBDE concentrations were estimated via multiple imputation. The Wechsler Intelligence Scales for Children-IV and the Behavior Assessment System for Children-2 was used to assess intelligence and externalizing behavior, respectively, in children at 8 years. We used multiple informant models to estimate associations between repeated lipid-adjusted PBDEs and child neurobehavior and to test for windows of susceptibility.Postnatal exposure to PBDE congeners (- 28, - 47, - 99, - 100, and - 153) at multiple ages was inversely associated with FSIQ at 8 years. For instance, a 10-fold increase in BDE-153 concentrations at 2, 3, 5, and 8 years were all related to lower FSIQ at age 8 (β for 3 years: - 7.7-points, 95% CI - 12.5, - 2.9; β for 8 years: - 5.6-points, 95% CI - 10.8, - 0.4). Multiple PBDE congeners at 8 years were associated with increased hyperactivity and aggressive behaviors at 8 years.Postnatal PBDE exposure was associated with decrements in FSIQ and increases in hyperactivity and aggressive behaviors.

PubMed ID: 28734254 Exiting the NIEHS site

MeSH Terms: Attention Deficit Disorder with Hyperactivity/chemically induced*; Attention Deficit Disorder with Hyperactivity/epidemiology*; Child; Environmental Exposure*; Environmental Pollutants/blood; Environmental Pollutants/toxicity; Female; Flame Retardants/analysis; Flame Retardants/toxicity; Halogenated Diphenyl Ethers/blood*; Halogenated Diphenyl Ethers/toxicity*; Humans; Intelligence Tests*; Male; Ohio; Prospective Studies

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