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Publication Detail

Title: Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis.

Authors: Armstrong, Laura E; Guo, Grace L

Published In Curr Pharmacol Rep, (2017 Apr)

Abstract: About 15-25% of patients with simple steatosis of non-alcoholic fatty liver disease progresses to non-alcoholic steatohepatitis (NASH), and the underlying mechanism for this progression has not been elucidated. NASH ultimately could progress to cirrhosis, an irreversible condition.Farnesoid X receptor (FXR) has been studied for its role in modulating inflammation, and the expression of FXR is down-regulated during NASH development. FXR deficiency has shown to progress and exacerbate NASH development, and FXR activation has been protective against liver inflammation associated with NASH. The expression of factors in both the adaptive and innate immune response in the liver are regulated in a FXR-dependent and -independent manner.Therefore, understanding key signaling pathways of liver inflammation in NASH is important to determine essential components that predispose, progress, or exacerbate NASH. FXR has been identified as a therapeutic target for NASH to prevent liver inflammation.

PubMed ID: 28983452 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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