Skip Navigation

Publication Detail

Title: Effects of chronic perfluorooctanoic acid (PFOA) at low concentration on morphometrics, gene expression, and fecundity in zebrafish (Danio rerio).

Authors: Jantzen, Carrie E; Toor, Fatima; Annunziato, Kate A; Cooper, Keith R

Published In Reprod Toxicol, (2017 Apr)

Abstract: Perfluorooctanoic acid (PFOA) is a persistent, toxic, anthropogenic chemical recalcitrant to biodegradation. Based on previous studies in lower and higher vertebrates, it was hypothesized that chronic, sub-lethal, embryonic exposure to PFOA in zebrafish (Danio rerio) would adversely impact fish development, survival, and fecundity. Zebrafish embryo/sac-fry were water exposed to 2.0 or 0nM PFOA from 3 to 120hpf, and juvenile to adult cohorts were fed spiked food (8 pM) until 6 months. After chronic exposure, PFOA exposed fish were significantly smaller in total weight and length. Gene expression analysis found a significant decrease of transporters slco2b1, slco4a1, slco3a1 and tgfb1a, and a significant increase of slco1d1 expression. PFOA exposed fish produced significantly fewer eggs with reduced viability and developmental stage delay in F1. Chronic, low-dose exposure of zebrafish to PFOA significantly altered normal development, survival and fecundity and would likely impact wild fish population fitness in watersheds chronically exposed to PFOA.

PubMed ID: 28143724 Exiting the NIEHS site

MeSH Terms: Animals; Caprylates/toxicity*; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/physiology; Embryonic Development/drug effects; Female; Fertility/drug effects; Fluorocarbons/toxicity*; Gene Expression Regulation, Developmental/drug effects; Male; Water Pollutants, Chemical/toxicity*; Zebrafish*/genetics; Zebrafish*/growth & development; Zebrafish*/physiology

Back
to Top