Title: The role of specialized pro-resolving mediators in maternal-fetal health.
Authors: Elliott, E; Hanson, C K; Anderson-Berry, A L; Nordgren, T M
Published In Prostaglandins Leukot Essent Fatty Acids, (2017 Nov)
Abstract: Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.
PubMed ID: 29031403
MeSH Terms: Docosahexaenoic Acids; Fatty Acids, Omega-3/metabolism*; Fatty Acids, Unsaturated/metabolism*; Female; Fetus; Humans; Infant; Infant, Newborn; Inflammation Mediators/metabolism; Inflammation/metabolism*; Inflammation/pathology; Maternal-Fetal Relations*; Pregnancy; Prenatal Care