Skip Navigation

Publication Detail

Title: Gestational tissue inflammatory biomarkers at term labor: A systematic review of literature.

Authors: Hadley, Emily E; Richardson, Lauren S; Torloni, Maria R; Menon, Ramkumar

Published In Am J Reprod Immunol, (2018 02)

Abstract: Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intra-uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro- and anti-inflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980-2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1β, COX-2, PGE-2, TNF-α, and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in pro-inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti-inflammatory markers at term labor are hardly reported.

PubMed ID: 29076197 Exiting the NIEHS site

MeSH Terms: Animals; Antimicrobial Cationic Peptides; Biomarkers/metabolism*; Cathelicidins/genetics; Cathelicidins/metabolism; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Female; Humans; Inflammation Mediators/metabolism*; Inflammation/immunology*; Metalloporphyrins/genetics; Metalloporphyrins/metabolism*; Parturition/immunology*; Pregnancy/immunology*; Uterus/physiology*

Back
to Top