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Title: The Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder.

Authors: Rubenstein, Eric; Edmondson Pretzel, Rebecca; Windham, Gayle C; Schieve, Laura A; Wiggins, Lisa D; DiGuiseppi, Carolyn; Olshan, Andrew F; Howard, Annie G; Pence, Brian W; Young, Lisa; Daniels, Julie

Published In J Autism Dev Disord, (2017 Oct)

Abstract: Autism spectrum disorder (ASD) diagnosis relies on parent-reported and clinician-observed instruments. Sometimes, results between these instruments disagree. The broader autism phenotype (BAP) in parent-reporters may be associated with discordance. Study to Explore Early Development data (N = 712) were used to address whether mothers with BAP and children with ASD or non-ASD developmental disabilities were more likely than mothers without BAP to 'over-' or 'under-report' child ASD on ASD screeners or interviews compared with clinician observation or overall impression. Maternal BAP was associated with a child meeting thresholds on a maternal-reported screener or maternal interview when clinician ASD instruments or impressions did not (risk ratios: 1.30 to 2.85). Evidence suggests acknowledging and accounting for reporting discordances may be important when diagnosing ASD.

PubMed ID: 28748335 Exiting the NIEHS site

MeSH Terms: Adult; Autism Spectrum Disorder/diagnosis*; Autism Spectrum Disorder/epidemiology; Autism Spectrum Disorder/psychology*; Case-Control Studies; Child; Child, Preschool; Developmental Disabilities/diagnosis; Developmental Disabilities/epidemiology; Developmental Disabilities/psychology; Female; Humans; Male; Mothers/psychology*; Phenotype*; Physician's Role/psychology*

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