Title: Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population.
Authors: Hsieh, S; Leaderer, B P; Feldstein, A E; Santoro, N; McKay, L A; Caprio, S; McConnell, R
Published In Pediatr Obes, (2018 06)
Abstract: Traffic-related air pollution causes fatty liver, inflammation and fibrosis in animal models, but there have been few studies in humans.To test the hypothesis that traffic-related air pollution causes non-alcoholic fatty liver disease (NAFLD) and increased markers for non-alcoholic steatohepatitis (NASH); and that NAFLD increases liver susceptibility to increased NASH risk.Data collected prospectively from 74 overweight or obese children were obtained from the Yale Pediatric Obesity Clinic. Traffic-related air pollution was characterized as vehicle traffic volume on major roads within a 1 km residential buffer, and as residential nitrogen dioxide (NO2 ) exposure. Outcomes were hepatic fat fraction (HFF) measured by magnetic resonance imaging, liver enzymes using standard assays and plasma cytokeratin-18 (CK-18) by immunosorbent assays.Significant non-linear relationships with air pollution and CK-18 were found. Plasma CK-18 at follow-up increased from approximately 150 U/L to almost 200 U/L as residential traffic volume increased from 220 000 vehicle-km to 330 000 vehicle-km, after adjustment for baseline CK-18, age and gender. Among patients with NAFLD at baseline, CK-18 increased from 140 U/L to 200 U/L (a 1.5 standard deviation increase in CK-18) as NO2 increased from 8 to 10 ppb.Traffic-related air pollution was associated with CK-18. Effects were larger in children with pre-existing NAFLD at study entry.
PubMed ID: 28730729
MeSH Terms: Air Pollutants/analysis; Air Pollution/adverse effects*; Apoptosis/physiology; Biomarkers/blood; Child; Female; Follow-Up Studies; Humans; Keratin-18/blood*; Liver/pathology; Magnetic Resonance Imaging; Male; Non-alcoholic Fatty Liver Disease/blood*; Non-alcoholic Fatty Liver Disease/complications; Non-alcoholic Fatty Liver Disease/etiology; Pediatric Obesity/complications*; Prospective Studies; Risk Factors; Traffic-Related Pollution/adverse effects*; Transaminases/blood; Vehicle Emissions/analysis