Title: The neurological toxicity of heavy metals: A fish perspective.

Authors: Green, Adrian J; Planchart, Antonio

Published In Comp Biochem Physiol C Toxicol Pharmacol, (2018 Jun)

Abstract: The causes of neurodegenerative diseases are complex with likely contributions from genetic susceptibility and environmental exposures over an organism's lifetime. In this review, we examine the role that aquatic models, especially zebrafish, have played in the elucidation of mechanisms of heavy metal toxicity and nervous system function over the last decade. Focus is applied to cadmium, lead, and mercury as significant contributors to central nervous system morbidity, and the application of numerous transgenic zebrafish expressing fluorescent reporters in specific neuronal populations or brain regions enabling high-resolution neurodevelopmental and neurotoxicology research.

PubMed ID: 29199130

MeSH Terms: Animals; Animals, Genetically Modified; Behavior, Animal/drug effects; Disease Models, Animal; Gene Expression Regulation, Developmental/drug effects; Heavy Metal Poisoning, Nervous System/etiology*; Heavy Metal Poisoning, Nervous System/genetics; Heavy Metal Poisoning, Nervous System/metabolism; Heavy Metal Poisoning, Nervous System/pathology; Humans; Metals, Heavy/toxicity*; Nerve Degeneration*; Nervous System/drug effects*; Nervous System/metabolism; Nervous System/pathology; Nervous System/physiopathology; Neurons/drug effects*; Neurons/metabolism; Neurons/pathology; Risk Assessment; Water Pollutants, Chemical/toxicity*; Zebrafish*/genetics; Zebrafish*/metabolism