Title: Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder.
Authors: Kerin, Tara; Volk, Heather; Li, Weiyan; Lurmann, Fred; Eckel, Sandrah; McConnell, Rob; Hertz-Picciotto, Irva
Published In J Autism Dev Disord, (2018 01)
Abstract: Prenatal exposure to air pollution has been associated with autism spectrum disorder (ASD) risk but no study has examined associations with ASD severity or functioning. Cognitive ability, adaptive functioning, and ASD severity were assessed in 327 children with ASD from the Childhood Autism Risks from Genetics and the Environment study using the Mullen Scales of Early Learning (MSEL), the Vineland Adaptive Behavior Scales (VABS), and the Autism Diagnostic Observation Schedule calibrated severity score. Estimates of nitrogen dioxide (NO2), particulate matter (PM2.5 and PM10), ozone, and near-roadway air pollution were assigned to each trimester of pregnancy and first year of life. Increasing prenatal and first year NO2 exposures were associated with decreased MSEL and VABS scores. Increasing PM10 exposure in the third trimester was paradoxically associated with improved performance on the VABS. ASD severity was not associated with air pollution exposure.
PubMed ID: 28921105
MeSH Terms: Adaptation, Psychological/physiology*; Air Pollution/adverse effects*; Autism Spectrum Disorder/diagnosis; Autism Spectrum Disorder/epidemiology*; Autism Spectrum Disorder/psychology; California/epidemiology; Case-Control Studies; Child; Child, Preschool; Cognition/physiology*; Environmental Exposure/adverse effects; Female; Humans; Male; Particulate Matter/adverse effects; Pregnancy; Prenatal Exposure Delayed Effects/diagnosis; Prenatal Exposure Delayed Effects/epidemiology*; Prenatal Exposure Delayed Effects/psychology; Severity of Illness Index*