Title: Sexually Dimorphic Effects of Early-Life Exposures to Endocrine Disruptors: Sex-Specific Epigenetic Reprogramming as a Potential Mechanism.
Authors: McCabe, Carolyn; Anderson, Olivia S; Montrose, Luke; Neier, Kari; Dolinoy, Dana C
Published In Curr Environ Health Rep, (2017 12)
Abstract: The genetic material of every organism exists within the context of regulatory networks that govern gene expression-collectively called the epigenome. Animal models and human birth cohort studies have revealed key developmental periods that are important for epigenetic programming and vulnerable to environmental insults. Thus, epigenetics represent a potential mechanism through which sexually dimorphic effects of early-life exposures such as endocrine-disrupting chemicals (EDCs) manifest.Several animal studies, and to a lesser extent human studies, have evaluated life-course sexually dimorphic health effects following developmental toxicant exposures; many fewer studies, however, have evaluated epigenetics as a mechanism mediating developmental exposures and later outcomes. To evaluate epigenetic reprogramming as a mechanistic link of sexually dimorphic early-life EDCs exposures, the following criteria should be met: (1) well-characterized exposure paradigm that includes relevant windows for developmental epigenetic reprogramming; (2) evaluation of sex-specific exposure-related epigenetic change; and (3) observation of a sexually dimorphic phenotype in either childhood, adolescence, or adulthood.
PubMed ID: 28980159
MeSH Terms: Animals; Benzhydryl Compounds/toxicity; DNA Methylation/drug effects; Endocrine Disruptors/adverse effects*; Epigenesis, Genetic/drug effects*; Female; Humans; Lead/toxicity; Phenols/toxicity; Pregnancy; Prenatal Exposure Delayed Effects/genetics*