Skip Navigation

Publication Detail

Title: The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity.

Authors: La Merrill, M A; Lind, P M; Salihovic, S; van Bavel, B; Lind, L

Published In Environ Res, (2018 01)

Abstract: The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass.p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques.We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%).The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.

PubMed ID: 29106953 Exiting the NIEHS site

MeSH Terms: Adiposity/physiology; Aged; Aged, 80 and over; Blood Glucose/analysis; Cohort Studies; Dichlorodiphenyl Dichloroethylene/toxicity*; Environmental Pollutants/toxicity*; Female; Heart Ventricles/physiopathology*; Humans; Hypertension/complications; Hypertension/epidemiology; Hypertrophy, Left Ventricular/chemically induced; Hypertrophy, Left Ventricular/epidemiology*; Insecticides/toxicity*; Male; Obesity/chemically induced; Obesity/epidemiology*; Prevalence; Risk Factors; Sweden/epidemiology

Back
to Top