Title: Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs.

Authors: Griffin, Brendan T; Guo, Jianfeng; Presas, Elena; Donovan, Maria D; Alonso, María J; O'Driscoll, Caitriona M

Published In Adv Drug Deliv Rev, (2016 Nov 15)

Abstract: The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic and biodistribution profiles of peptide- and protein-like drugs following oral administration is critically reviewed. The possible mechanisms of absorption enhancement and the effects of the physicochemical properties of the NP are examined. The potential advantages and challenges of physiologically-based pharmacokinetic (PBPK) modelling to help predict efficacy in man are discussed. The importance of developing and expanding the regulatory framework to help translate the technology into the clinic and accelerate the availability of oral nanoparticulate formulations is emphasized. In conclusion, opportunities for future work to improve the state of the art of oral nanomedicines are identified.

PubMed ID: 27320644

MeSH Terms: Administration, Oral; Animals; Drug Carriers/administration & dosage*; Drug Carriers/pharmacokinetics*; Humans; Nanoparticles/administration & dosage*; Nanoparticles/metabolism; Peptides/administration & dosage*; Peptides/pharmacokinetics*; Pharmaceutical Preparations/administration & dosage*; Pharmaceutical Preparations/metabolism; Proteins/administration & dosage*; Proteins/pharmacokinetics*; Tissue Distribution