Title: Analysis of Gene-Gene Interactions.
Authors: Cole, Brian S; Hall, Molly A; Urbanowicz, Ryan J; Gilbert-Diamond, Diane; Moore, Jason H
Published In Curr Protoc Hum Genet, (2017 10 18)
Abstract: The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research. © 2017 by John Wiley & Sons, Inc.
PubMed ID: 29044470
MeSH Terms: Algorithms; Animals; Epistasis, Genetic*; Gene Expression Regulation*; Genetic Association Studies/methods; Genetic Predisposition to Disease; Genomics*/methods; Humans; Machine Learning; Models, Statistical