Title: Association between Exposure to Ambient Air Particulates and Metabolic Syndrome Components in a Saudi Arabian Population.
Authors: Shamy, Magdy; Alghamdi, Mansour; Khoder, Mamdouh I; Mohorjy, Abdullah M; Alkhatim, Alser A; Alkhalaf, Abdulrahman K; Brocato, Jason; Chen, Lung Chi; Thurston, George D; Lim, Chris C; Costa, Max
Published In Int J Environ Res Public Health, (2017 12 25)
Abstract: Recent epidemiological evidence suggests that exposure to particulates may be a factor in the etiology of metabolic syndrome (MetS). In this novel study, we investigated the relationship between particulate levels and prevalence of MetS component abnormalities (hypertension, hyperglycemia, obesity) in a recruited cohort (N = 2025) in Jeddah, Saudi Arabia. We observed significant associations between a 10 μg/m³ increase in PM2.5 and increased risks for MetS (Risk Ratio (RR): 1.12; 95% Confidence Interval (CI): 1.06-1.19), hyperglycemia (RR: 1.08; 95% CI: 1.03-1.14), and hypertension (RR: 1.09; 95% CI: 1.04-1.14). PM2.5 from soil/road dust was found to be associated with hyperglycemia (RR: 1.12; 95% CI: 1.06-1.19) and hypertension (RR: 1.11; 95% CI: 1.05-1.18), while PM2.5 from traffic was associated with hyperglycemia (RR: 1.33; 95% CI: 1.05-1.71). We did not observe any health associations with source-specific mass exposures. Our findings suggest that exposure to specific elemental components of PM2.5, especially Ni, may contribute to the development of cardiometabolic disorders.
PubMed ID: 29295575
MeSH Terms: Adult; Air Pollutants/adverse effects; Air Pollutants/analysis; Cohort Studies; Dust/analysis*; Environmental Exposure/adverse effects*; Environmental Exposure/analysis; Female; Humans; Hyperglycemia/epidemiology; Hyperglycemia/etiology*; Hypertension/epidemiology; Hypertension/etiology*; Male; Metabolic Syndrome/epidemiology; Metabolic Syndrome/etiology*; Middle Aged; Particulate Matter/adverse effects*; Particulate Matter/analysis*; Prevalence; Saudi Arabia/epidemiology