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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Epithelial Cell Regulation of Allergic Diseases.

Authors: Gour, Naina; Lajoie, Stephane

Published In Curr Allergy Asthma Rep, (2016 Sep)

Abstract: Allergic diseases, which have escalated in prevalence in recent years, arise as a result of maladaptive immune responses to ubiquitous environmental stimuli. Why only certain individuals mount inappropriate type 2 immune responses to these otherwise harmless allergens has remained an unanswered question. Mounting evidence suggests that the epithelium, by sensing its environment, is the central regulator of allergic diseases. Once considered to be a passive barrier to allergens, epithelial cells at mucosal surfaces are now considered to be the cornerstone of the allergic diathesis. Beyond their function as maintaining barrier at mucosal surfaces, mucosal epithelial cells through the secretion of mediators like IL-25, IL-33, and TSLP control the fate of downstream allergic immune responses. In this review, we will discuss the advances in recent years regarding the process of allergen recognition and secretion of soluble mediators by epithelial cells that shape the development of the allergic response.

PubMed ID: 27534656 Exiting the NIEHS site

MeSH Terms: Allergens/immunology*; Animals; Epithelial Cells/immunology*; Humans

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