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Title: Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.

Authors: Walker, Douglas I; Pennell, Kurt D; Uppal, Karan; Xia, Xiaoyan; Hopke, Philip K; Utell, Mark J; Phipps, Richard P; Sime, Patricia J; Rohrbeck, Patricia; Mallon, Col Timothy M; Jones, Dean P

Published In J Occup Environ Med, (2016 Aug)

Abstract: A pilot study was conducted to test the feasibility of using Department of Defense Serum Repository (DoDSR) samples to study health and exposure-related effects.Thirty unidentified human serum samples were obtained from the DoDSR and analyzed for normal serum metabolites with high-resolution mass spectrometry and serum levels of free benzo(a)pyrene (BaP) by gas chromatography-mass spectrometry. Metabolic associations with BaP were determined using a metabolome-wide association study (MWAS) and metabolic pathway enrichment.The serum analysis detected normal ranges of glucose, selected amino acids, fatty acids, and creatinine. Free BaP was detected in a broad concentration range. MWAS of BaP showed associations with lipids, fatty acids, and sulfur amino acid metabolic pathways.The results show that the DoDSR samples are of sufficient quality for chemical profiling of DoD personnel.

PubMed ID: 27501104 Exiting the NIEHS site

MeSH Terms: Benzo(a)pyrene/analysis*; Blood Banks; Environmental Exposure/adverse effects; Humans; Mass Spectrometry; Metabolome*; Military Personnel*; Occupational Exposure/adverse effects; Pilot Projects; Serum/chemistry*

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