Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease.

Authors: Nativio, Raffaella; Donahue, Greg; Berson, Amit; Lan, Yemin; Amlie-Wolf, Alexandre; Tuzer, Ferit; Toledo, Jon B; Gosai, Sager J; Gregory, Brian D; Torres, Claudio; Trojanowski, John Q; Wang, Li-San; Johnson, F Brad; Bonini, Nancy M; Berger, Shelley L

Published In Nat Neurosci, (2018 04)

Abstract: Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-associated neurodegeneration. Here we compare the genome-wide enrichment of H4K16ac in the lateral temporal lobe of AD individuals against both younger and elderly cognitively normal controls. We found that while normal aging leads to H4K16ac enrichment, AD entails dramatic losses of H4K16ac in the proximity of genes linked to aging and AD. Our analysis highlights the presence of three classes of AD-related changes with distinctive functional roles. Furthermore, we discovered an association between the genomic locations of significant H4K16ac changes with genetic variants identified in prior AD genome-wide association studies and with expression quantitative trait loci. Our results establish the basis for an epigenetic link between aging and AD.

PubMed ID: 29507413 Exiting the NIEHS site

MeSH Terms: Aged; Aging*; Alzheimer Disease*/genetics; Alzheimer Disease*/pathology; Alzheimer Disease*/physiopathology; Analysis of Variance; Brain/metabolism; Brain/pathology*; Chromatin Immunoprecipitation; Epigenesis, Genetic/physiology*; Epigenomics/methods*; Female; Genome-Wide Association Study; Histone Deacetylase 1/genetics; Histone Deacetylase 1/metabolism*; Humans; Male; Middle Aged

Back
to Top