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National Institute of Environmental Health Sciences

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Publication Detail

Title: NRF2 and the Hallmarks of Cancer.

Authors: Rojo de la Vega, Montserrat; Chapman, Eli; Zhang, Donna D

Published In Cancer Cell, (2018 07 09)

Abstract: The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

PubMed ID: 29731393 Exiting the NIEHS site

MeSH Terms: Animals; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Cell Transformation, Neoplastic/pathology; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism*; Neoplasm Metastasis; Neoplasms/drug therapy; Neoplasms/genetics; Neoplasms/metabolism*; Neoplasms/pathology; Signal Transduction*/drug effects

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