Title: Regulation of chromatin and gene expression by metabolic enzymes and metabolites.
Authors: Li, Xinjian; Egervari, Gabor; Wang, Yugang; Berger, Shelley L; Lu, Zhimin
Published In Nat Rev Mol Cell Biol, (2018 09)
Abstract: Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly - through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators. Deregulation of these metabolic activities has been implicated in human diseases, prominently including cancer.
PubMed ID: 29930302
MeSH Terms: Animals; Chromatin/physiology*; Gene Expression Regulation/physiology*; Histone Code/physiology; Histones/metabolism; Humans; Transcription Factors/metabolism*