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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.

Authors: D'Souza, Jennifer C; Kawut, Steven M; Elkayam, Laura R; Sheppard, Lianne; Thorne, Peter S; Jacobs Jr, David R; Bluemke, David A; Lima, Joao A C; Kaufman, Joel D; Larson, Timothy V; Adar, Sara D

Published In Environ Health Perspect, (2017 07 27)

Abstract: BACKGROUND: Coarse particulate matter (P10-2.5) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM10-2.5 is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM10-2.5 remain unknown. OBJECTIVES: To quantify cross-sectional associations between RV dysfunction and PM10-2.5 mass and components among older adults and susceptible populations. METHODS: We used baseline cardiac magnetic resonance images from 1,490 participants (45-84 y old) from the Multi-Ethnic Study of Atherosclerosis and assigned 5-y residential concentrations of PM10-2.5 mass, copper, zinc, phosphorus, silicon, and endotoxin, using land-use regression models. We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants using linear regression. We further examined personal susceptibility. RESULTS: We found positive associations of RV mass and, to a lesser extent, end diastolic volume with PM10-2.5 mass among susceptible populations including smokers and persons with emphysema. After adjustment for copollutants, an interquartile range increase in PM10-2.5 mass (2.2 μg/m3) was associated with 0.5 g (95% CI: 0.0, 1.0), 0.9 g (95% CI: 0.1, 1.7), and 1.4 g (95% CI: 0.4, 2.5) larger RV mass among former smokers, current smokers, and persons with emphysema, respectively. No associations were found with healthy individuals or with ejection fraction. CONCLUSIONS: Alterations to RV structure may represent a mechanism by which long-term PM10-2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. https://doi.org/10.1289/EHP658.

PubMed ID: 28760719 Exiting the NIEHS site

MeSH Terms: Aged; Aged, 80 and over; Atherosclerosis/chemically induced; Atherosclerosis/ethnology; Atherosclerosis/physiopathology*; Chicago/epidemiology; Cross-Sectional Studies; Environmental Exposure*; Environmental Pollutants/toxicity*; Female; Humans; Male; Middle Aged; Minnesota/epidemiology; North Carolina/epidemiology; Particle Size; Particulate Matter/toxicity*; Risk Factors; Ventricular Dysfunction, Right/chemically induced; Ventricular Dysfunction, Right/ethnology; Ventricular Dysfunction, Right/physiopathology*

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