Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts.

Authors: Contreras, Zuelma A; Chen, Zhanghua; Roumeliotaki, Theano; Annesi-Maesano, Isabella; Baïz, Nour; von Berg, Andrea; Bergström, Anna; Crozier, Sarah; Duijts, Liesbeth; Ekström, Sandra; Eller, Esben; Fantini, Maria P; Kjaer, Henrik Fomsgaard; Forastiere, Francesco; Gerhard, Beatrix; Gori, Davide; Harskamp-van Ginkel, Margreet W; Heinrich, Joachim; Iñiguez, Carmen; Inskip, Hazel; Keil, Thomas; Kogevinas, Manolis; Lau, Susanne; Lehmann, Irina; Maier, Dieter; van Meel, Evelien R; Mommers, Monique; Murcia, Mario; Porta, Daniela; Smit, Henriëtte A; Standl, Marie; Stratakis, Nikos; Sunyer, Jordi; Thijs, Carel; Torrent, Maties; Vrijkotte, Tanja G M; Wijga, Alet H; Berhane, Kiros; Gilliland, Frank; Chatzi, Leda

Published In Eur Respir J, (2018 09)

Abstract: The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3-4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3-4 years of age.Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18-2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31-3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08-2.09).Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.

PubMed ID: 30209194 Exiting the NIEHS site

MeSH Terms: Age of Onset; Asthma/diagnosis*; Asthma/epidemiology*; Child; Child, Preschool; Cohort Studies; Europe/epidemiology; Female; Humans; Male; Pediatric Obesity/epidemiology*; Phenotype; Respiratory Sounds/diagnosis*; Respiratory Sounds/physiopathology; Rhinitis, Allergic/epidemiology; Risk Factors

Back
to Top