Title: C. elegans-An Emerging Model to Study Metal-Induced RAGE-Related Pathologies.
Authors: Pinkas, Adi; Cunha Martins Jr, Airton; Aschner, Michael
Published In Int J Environ Res Public Health, (2018 07 04)
Abstract: The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, C. elegans has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.
PubMed ID: 29973513
MeSH Terms: Animals; Caenorhabditis elegans/physiology*; Glycation End Products, Advanced/toxicity*; Humans; Inflammation/etiology; Inflammation/physiopathology*; Metals/toxicity*; Models, Animal; Oxidative Stress/physiology*; Receptor for Advanced Glycation End Products/physiology*