Title: Epigenetic mechanisms in the placenta related to infant neurodevelopment.
Authors: Lester, Barry M; Marsit, Carmen J
Published In Epigenomics, (2018 03 01)
Abstract: As the 'third brain' the placenta links the developing fetal brain and the maternal brain enabling study of epigenetic process in placental genes that affect infant neurodevelopment. We described the characteristics and findings of the 17 studies on epigenetic processes in placental genes and human infant neurobehavior. Studies showed consistent findings in the same cohort of term healthy infants across epigenetic processes (DNA methylation, genome wide, gene and miRNA expression) genomic region (single and multiple genes, imprinted genes and miRNAs) using candidate gene and genome wide approaches and across biobehavioral systems (neurobehavior, cry acoustics and neuroendocrine). Despite limitations, studies support future work on molecular processes in placental genes related to neurodevelopmental trajectories including implications for intervention.
PubMed ID: 29381081
MeSH Terms: Arousal/genetics; Attention/physiology; Brain/growth & development; Brain/metabolism; CpG Islands; DNA Methylation*; Epigenesis, Genetic*; Female; Fetal Development/genetics; Fetus; Genome, Human; Humans; Infant; Infant Behavior/physiology*; Lethargy/genetics; Lethargy/metabolism; Lethargy/physiopathology; MicroRNAs/genetics*; MicroRNAs/metabolism; Motor Activity/genetics; Neurogenesis/genetics; Neurosecretory Systems/growth & development; Neurosecretory Systems/metabolism*; Placenta/metabolism*; Pregnancy