Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Tissue Engineering for the Temporomandibular Joint.

Authors: Acri, Timothy M; Shin, Kyungsup; Seol, Dongrim; Laird, Noah Z; Song, Ino; Geary, Sean M; Chakka, Jaidev L; Martin, James A; Salem, Aliasger K

Published In Adv Healthc Mater, (2019 01)

Abstract: Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients' quality of life. Effective treatment options for patients suffering from severe temporomandibular joint disorders are in high demand because surgical options are restricted to removal of damaged tissue or complete replacement of the joint with prosthetics. Tissue engineering approaches for the temporomandibular joint are a promising alternative to the limited clinical treatment options. However, tissue engineering is still a developing field and only in its formative years for the temporomandibular joint. This review outlines the anatomical and physiological characteristics of the temporomandibular joint, clinical management of temporomandibular joint disorder, and current perspectives in the tissue engineering approach for the temporomandibular joint disorder. The tissue engineering perspectives have been categorized according to the primary structures of the temporomandibular joint: the disc, the mandibular condyle, and the glenoid fossa. In each section, contemporary approaches in cellularization, growth factor selection, and scaffold fabrication strategies are reviewed in detail along with their achievements and challenges.

PubMed ID: 30556348 Exiting the NIEHS site

MeSH Terms: Animals; Glenoid Cavity/anatomy & histology; Glenoid Cavity/cytology; Glenoid Cavity/physiology; Humans; Intercellular Signaling Peptides and Proteins/metabolism; Intercellular Signaling Peptides and Proteins/pharmacology; Mandibular Condyle/anatomy & histology; Mandibular Condyle/cytology; Stem Cells/cytology; Stem Cells/physiology; Temporomandibular Joint Disc/anatomy & histology; Temporomandibular Joint Disc/cytology; Temporomandibular Joint Disorders/diagnosis; Temporomandibular Joint Disorders/etiology; Temporomandibular Joint Disorders/surgery*; Temporomandibular Joint*/anatomy & histology; Temporomandibular Joint*/physiology; Tissue Engineering/methods*; Tissue Scaffolds

Back
to Top