Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Key Characteristics Approach to Carcinogenic Hazard Identification.

Authors: Guyton, Kathryn Z; Rieswijk, Linda; Wang, Amy; Chiu, Weihsueh A; Smith, Martyn T

Published In Chem Res Toxicol, (2018 Dec 17)

Abstract: Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.

PubMed ID: 30521319 Exiting the NIEHS site

MeSH Terms: Biomarkers/metabolism; Carcinogenicity Tests; Carcinogens/chemistry*; Carcinogens/toxicity; DNA Damage/drug effects; Epigenesis, Genetic/drug effects; Genomic Instability/drug effects; Humans; Neoplasms/metabolism; Neoplasms/pathology; Oxidative Stress/drug effects

Back
to Top