Title: Key Characteristics Approach to Carcinogenic Hazard Identification.
Authors: Guyton, Kathryn Z; Rieswijk, Linda; Wang, Amy; Chiu, Weihsueh A; Smith, Martyn T
Published In Chem Res Toxicol, (2018 12 17)
Abstract: Evaluating carcinogenic mechanisms is a challenging part of hazard identification, as mechanistic data are both voluminous and diverse. An evaluation approach based on 10 key characteristics of human carcinogens provides a holistic and unbiased way to tackle this challenge.
PubMed ID: 30521319
MeSH Terms: Biomarkers/metabolism; Carcinogenicity Tests; Carcinogens/chemistry*; Carcinogens/toxicity; DNA Damage/drug effects; Epigenesis, Genetic/drug effects; Genomic Instability/drug effects; Humans; Neoplasms/metabolism; Neoplasms/pathology; Oxidative Stress/drug effects