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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Anti-inflammatory effects of newly synthesized α-galacto-oligosaccharides on dextran sulfate sodium-induced colitis in C57BL/6J mice.

Authors: Dai, Zhuqing; Feng, Simin; Liu, Anna; Wang, Hong; Zeng, Xiaoxiong; Yang, Chung S

Published In Food Res Int, (2018 Jul)

Abstract: α-Galacto-oligosaccharides have been reported to have beneficial health effects. The purpose of this study was to investigate the preventive effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), as well as raffinose family oligosaccharides (RFOs), on dextran sulfate sodium (DSS)-induced colitis in mice. When administered in drinking water at 0.5% for 15 days, both α-GOSg and RFOs significantly decreased fecal hemoglobin content, partially prevented colon length shortening, reduced the severity of colon inflammation, and attenuated DSS-induced upregulation of cyclooxygenase-2. In addition, the activation of the inflammatory regulator nuclear factor-kappa B was slightly inhibited by α-GOSg. The results showed that the newly synthesized α-GOSg preparation has similar anti-inflammatory activities as RFOs in this colitis model. The anti-inflammatory activity of α-GOSg in humans remains to be investigated.

PubMed ID: 29803460 Exiting the NIEHS site

MeSH Terms: Animals; Anti-Inflammatory Agents/chemical synthesis; Anti-Inflammatory Agents/pharmacology*; Colitis/chemically induced; Colitis/metabolism; Colitis/pathology; Colitis/prevention & control*; Colon/drug effects*; Colon/metabolism; Colon/pathology; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Dextran Sulfate*; Diet, High-Fat; Diet, Western; Disease Models, Animal; Feces/chemistry; Hemoglobins/metabolism; Macrophage Colony-Stimulating Factor/genetics; Macrophage Colony-Stimulating Factor/metabolism; Male; Mice, Inbred C57BL; Oligosaccharides/chemical synthesis; Oligosaccharides/pharmacology*; Transcription Factor RelA/metabolism

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