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Publication Detail

Title: Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs.

Authors: Nordgren, Tara M; Anderson Berry, Ann; Van Ormer, Matthew; Zoucha, Samuel; Elliott, Elizabeth; Johnson, Rebecca; McGinn, Elizabeth; Cave, Caleb; Rilett, Katherine; Weishaar, Kara; Maddipati, Sai Sujana; Appeah, Harriet; Hanson, Corrine

Published In Nutrients, (2019 Jan 05)

Abstract: Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 fatty acids serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory and immune-stimulating effects. The role SPM play in the protection against negative maternal-fetal health outcomes is unclear, and there are no current biomarkers of n-3 fatty acid sufficiency. We sought to ascertain the relationships between n-3 fatty acid intake, SPM levels, and maternal-fetal health outcomes. We obtained n-3 fatty acid intake information from 136 mothers admitted for delivery using a food frequency questionnaire and measured docosahexaenoic acid (DHA)-derived SPMs resolvin D1 (RvD1) and RvD2 in maternal and cord plasma. We found significantly elevated SPM in maternal versus cord plasma, and increased SPM levels were associated with at-risk outcomes. We also identified that increased DHA intake was associated with elevated maternal plasma RvD1 (p = 0.03; R² = 0.18) and RvD2 (p = 0.04; R² = 0.20) in the setting of neonatal intensive care unit (NICU) admission. These findings indicate that increased n-3 fatty acid intake may provide increased substrate for the production of SPM during high-risk pregnancy/delivery conditions, and that increased maternal plasma SPM could serve as a biomarker for negative neonatal outcomes.

PubMed ID: 30621269 Exiting the NIEHS site

MeSH Terms: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents; Diet Records; Dietary Supplements; Docosahexaenoic Acids/administration & dosage*; Docosahexaenoic Acids/blood; Fatty Acids, Omega-3/administration & dosage*; Female; Fetal Blood/chemistry; Humans; Infant, Newborn; Intensive Care, Neonatal; Male; Pregnancy; Pregnancy Outcome*; Pregnancy, High-Risk; Prenatal Care; Surveys and Questionnaires

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