Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs.

Authors: Nordgren, Tara M; Anderson Berry, Ann; Van Ormer, Matthew; Zoucha, Samuel; Elliott, Elizabeth; Johnson, Rebecca; McGinn, Elizabeth; Cave, Caleb; Rilett, Katherine; Weishaar, Kara; Maddipati, Sai Sujana; Appeah, Harriet; Hanson, Corrine

Published In Nutrients, (2019 Jan 05)

Abstract: Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 fatty acids serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory and immune-stimulating effects. The role SPM play in the protection against negative maternal-fetal health outcomes is unclear, and there are no current biomarkers of n-3 fatty acid sufficiency. We sought to ascertain the relationships between n-3 fatty acid intake, SPM levels, and maternal-fetal health outcomes. We obtained n-3 fatty acid intake information from 136 mothers admitted for delivery using a food frequency questionnaire and measured docosahexaenoic acid (DHA)-derived SPMs resolvin D1 (RvD1) and RvD2 in maternal and cord plasma. We found significantly elevated SPM in maternal versus cord plasma, and increased SPM levels were associated with at-risk outcomes. We also identified that increased DHA intake was associated with elevated maternal plasma RvD1 (p = 0.03; R² = 0.18) and RvD2 (p = 0.04; R² = 0.20) in the setting of neonatal intensive care unit (NICU) admission. These findings indicate that increased n-3 fatty acid intake may provide increased substrate for the production of SPM during high-risk pregnancy/delivery conditions, and that increased maternal plasma SPM could serve as a biomarker for negative neonatal outcomes.

PubMed ID: 30621269 Exiting the NIEHS site

MeSH Terms: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents; Diet Records; Dietary Supplements; Docosahexaenoic Acids/administration & dosage*; Docosahexaenoic Acids/blood; Fatty Acids, Omega-3/administration & dosage*; Female; Fetal Blood/chemistry; Humans; Infant, Newborn; Intensive Care, Neonatal; Male; Pregnancy; Pregnancy Outcome*; Pregnancy, High-Risk; Prenatal Care; Surveys and Questionnaires

to Top