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Title: Population-based birth defects data in the United States, 2011-2015: A focus on eye and ear defects.

Authors: Stallings, Erin B; Isenburg, Jennifer L; Mai, Cara T; Liberman, Rebecca F; Moore, Cynthia A; Canfield, Mark A; Salemi, Jason L; Kirby, Russell S; Short, Tyiesha D; Nembhard, Wendy N; Forestieri, Nina E; Heinke, Dominique; Alverson, C J; Romitti, Paul A; Huynh, My-Phuong; Denson, Lindsay E; Judson, Emily M; Lupo, Philip J; National Birth Defects Prevention Network

Published In Birth Defects Res, (2018 11 15)

Abstract: In this data brief, we examine major eye and ear anomalies (anophthalmia/microphthalmia, anotia/microtia, and congenital cataract) for a recent 5-year birth cohort using data from 30 population-based birth defects surveillance programs in the United States.As a special call for data for the 2018 NBDPN Annual Report, state programs reported expanded data on eye/ear anomalies for birth years 2011-2015. We calculated the combined overall prevalence (per 10,000 live births) and 95% confidence intervals (CI), for the three anomalies as well as by maternal age, maternal race/ethnicity, infant sex, laterality, presence/absence of other major birth defects, and case ascertainment methodology utilized by the program (active vs. passive).The overall prevalence estimate (per 10,000 live births) was 1.5 (95% CI: 1.4-1.5) for anophthalmia/microphthalmia, 1.5 (95% CI: 1.4-1.6) for congenital cataract, and 1.8 (95% CI: 1.7-1.8) for anotia/microtia. Congenital cataract prevalence varied little by maternal race/ethnicity, infant sex, or case ascertainment methodology; prevalence differences were more apparent across strata for anophthalmia/microphthalmia and anotia/microtia. Prevalence among active vs. passive ascertainment programs was 50% higher for anophthalmia/microphthalmia (1.9 vs. 1.2) and two-fold higher for anotia/microtia (2.6 vs. 1.2). Anophthalmia/microphthalmia was more likely than other conditions to co-occur with other birth defects. All conditions were more frequent among older mothers (40+ years).This data brief provides recent prevalence estimates for anophthalmia/microphthalmia, congenital cataract, and anotia/microtia that address a data gap by examining pooled data from 30 population-based surveillance systems, covering a five-year birth cohort of about 12.4 million births.

PubMed ID: 30444307 Exiting the NIEHS site

MeSH Terms: Adult; Anophthalmos/epidemiology*; Case-Control Studies; Cataract/epidemiology; Congenital Abnormalities/epidemiology; Congenital Microtia/epidemiology*; Ear/abnormalities; Eye Abnormalities; Female; Humans; Infant; Infant, Newborn; Logistic Models; Male; Maternal Age; Microphthalmos/epidemiology*; Mothers; Odds Ratio; Population Surveillance/methods; Pregnancy; Prevalence; Registries; Risk Factors; United States

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