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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Microbial Unmasking of Plant Glycosides.

Authors: Biernat, Kristen A; Li, Bo; Redinbo, Matthew R

Published In mBio, (2018 01 30)

Abstract: The therapeutic potential of plants is widely recognized and harnessed in plant-based remedies and drug discovery. However, the factors that modulate the bioavailability and bioactivities of plant-derived phytochemicals are poorly understood. In a recent article in mBio, M. C. Theilmann et al. (mBio 8:e01421-17, 2017, https://doi.org/10.1128/mBio.01421-17) describe how one gut microbe, Lactobacillus acidophilus, catalytically unwraps plant glucosides to make deglucosylated bioactive aglycones available to human tissues. They demonstrate that understanding the metabolism of plant glycosides by intestinal bacteria is essential to appreciating how bacteria manipulate the levels of bioactive plant metabolites in the human host.

PubMed ID: 29382739 Exiting the NIEHS site

MeSH Terms: Glycosides; Humans; Lactobacillus acidophilus*; Phytochemicals*

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