Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Shared heritability and functional enrichment across six solid cancers.

Authors: Jiang, Xia (see original citation for additional authors)

Published In Nat Commun, (2019 01 25)

Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

PubMed ID: 30683880 Exiting the NIEHS site

MeSH Terms: Breast Neoplasms/diagnosis; Breast Neoplasms/ethnology; Breast Neoplasms/genetics*; Breast Neoplasms/pathology; Case-Control Studies; Colorectal Neoplasms/diagnosis; Colorectal Neoplasms/ethnology; Colorectal Neoplasms/genetics*; Colorectal Neoplasms/pathology; European Continental Ancestry Group; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Head and Neck Neoplasms/diagnosis; Head and Neck Neoplasms/ethnology; Head and Neck Neoplasms/genetics*; Head and Neck Neoplasms/pathology; Humans; Inheritance Patterns*; Lung Neoplasms/diagnosis; Lung Neoplasms/ethnology; Lung Neoplasms/genetics*; Lung Neoplasms/pathology; Male; Mental Disorders/ethnology; Mental Disorders/genetics; Mental Disorders/physiopathology; Neoplasm Proteins/genetics; Ovarian Neoplasms/diagnosis; Ovarian Neoplasms/ethnology; Ovarian Neoplasms/genetics*; Ovarian Neoplasms/pathology; Phenotype; Polymorphism, Single Nucleotide; Prostatic Neoplasms/diagnosis; Prostatic Neoplasms/ethnology; Prostatic Neoplasms/genetics*; Prostatic Neoplasms/pathology; Smoking/ethnology; Smoking/genetics; Smoking/physiopathology

to Top