Title: Asthma and Corticosteroid Responses in Childhood and Adult Asthma.
Authors: Ramadan, Amira Ali; Gaffin, Jonathan M; Israel, Elliot; Phipatanakul, Wanda
Published In Clin Chest Med, (2019 03)
Abstract: Corticosteroids are the most effective treatment for asthma; inhaled corticosteroids (ICSs) are the first-line treatment for children and adults with persistent symptoms. ICSs are associated with significant improvements in lung function. The anti-inflammatory effects of corticosteroids are mediated by both genomic and nongenomic factors. Variation in the response to corticosteroids has been observed. Patient characteristics, biomarkers, and genetic features may be used to predict response to ICSs. The existence of multiple mechanisms underlying glucocorticoid insensitivity raises the possibility that this might indeed reflect different diseases with a common phenotype.
PubMed ID: 30691710
MeSH Terms: Administration, Inhalation; Adrenal Cortex Hormones/pharmacology; Adrenal Cortex Hormones/therapeutic use; Adult; Anti-Asthmatic Agents/pharmacology; Anti-Asthmatic Agents/therapeutic use*; Asthma/drug therapy*; Child; Humans; Treatment Outcome