Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice.

Authors: Woodward, Nicholas C; Crow, Amanda L; Zhang, Yang; Epstein, Sam; Hartiala, Jaana; Johnson, Richard; Kocalis, Heidi; Saffari, Arian; Sankaranarayanan, Ishwarya; Akbari, Omid; Ramanathan, Gajalakshmi; Araujo, Jesus A; Finch, Caleb E; Bouret, Sebastien G; Sioutas, Constantinos; Morgan, Todd E; Allayee, Hooman

Published In Sci Rep, (2019 02 12)

Abstract: Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM2.5) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. The goal of the present study was to determine the effects of prenatal and early life exposure to nPM on metabolic homeostasis in mice. C57BL/6 J mice were exposed to nPM or filtered air from gestation until 17 weeks of age and characterized for metabolic and behavioral parameters. In male mice, nPM exposure increased food intake, body weight, fat mass, adiposity, and whole-body glucose intolerance (p < 0.05). Consistent with these effects, male mice exposed to nPM displayed alterations in the expression of metabolically-relevant neuropeptides in the hypothalamus and decreased expression of insulin receptor signaling genes in adipose (p < 0.05). There were no differences in exploratory behavior or motor function, fasting lipid levels, or the inflammatory profile of adipose tissue. Our results provide evidence that chronic nPM exposure from gestation to early adulthood in male mice promotes metabolic dysregulation in part through modulation of feeding behavior and in the absence of an obesogenic diet.

PubMed ID: 30755631 Exiting the NIEHS site

MeSH Terms: Adiposity/drug effects; Animals; Body Composition/drug effects; Body Weight/drug effects; Eating/drug effects; Energy Metabolism/drug effects; Female; Flow Cytometry; Glucose Intolerance; Glucose Tolerance Test; Homeostasis/drug effects*; Insulin Resistance; Locomotion/drug effects; Mice; Mice, Inbred C57BL; Particulate Matter/toxicity*; Pregnancy

Back
to Top