Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Internet Explorer is no longer a supported browser.

This website may not display properly with Internet Explorer. For the best experience, please use a more recent browser such as the latest versions of Google Chrome, Microsoft Edge, and/or Mozilla Firefox. Thank you.

Your Environment. Your Health.

Publication Detail

Title: Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway.

Authors: Mascuch, Samantha J; Boudreau, Paul D; Carland, Tristan M; Pierce, N Tessa; Olson, Joshua; Hensler, Mary E; Choi, Hyukjae; Campanale, Joseph; Hamdoun, Amro; Nizet, Victor; Gerwick, William H; Gaasterland, Teresa; Gerwick, Lena

Published In J Nat Prod, (2018 03 23)

Abstract: The cyanobacterial marine natural product honaucin A inhibits mammalian innate inflammation in vitro and in vivo. To decipher its mechanism of action, RNA sequencing was used to evaluate differences in gene expression of cultured macrophages following honaucin A treatment. This analysis led to the hypothesis that honaucin A exerts its anti-inflammatory activity through activation of the cytoprotective nuclear erythroid 2-related factor 2 (Nrf2)-antioxidant response element/electrophile response element (ARE/EpRE) signaling pathway. Activation of this pathway by honaucin A in cultured human MCF7 cells was confirmed using an Nrf2 luciferase reporter assay. In vitro alkylation experiments with the natural product and N-acetyl-l-cysteine suggest that honaucin A activates this pathway through covalent interaction with the sulfhydryl residues of the cytosolic repressor protein Keap1. Honaucin A presents a potential therapeutic lead for diseases with an inflammatory component modulated by Nrf2-ARE.

PubMed ID: 29215273 Exiting the NIEHS site

MeSH Terms: Alkylation/drug effects; Animals; Anti-Inflammatory Agents/chemistry; Anti-Inflammatory Agents/pharmacology*; Antioxidants/metabolism; Aquatic Organisms/chemistry*; Biological Products/chemistry; Biological Products/pharmacology*; Cell Line; Cell Line, Tumor; Cytoprotection/drug effects; Female; Humans; Inflammation/drug therapy*; Inflammation/metabolism; Kelch-Like ECH-Associated Protein 1/metabolism; MCF-7 Cells; Mice; NF-E2-Related Factor 2/metabolism*; RAW 264.7 Cells; Signal Transduction/drug effects*

to Top