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National Institute of Environmental Health Sciences

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Publication Detail

Title: Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis.

Authors: Palmer, Brian C; Jatana, Samreen; Phelan-Dickinson, Sarah J; DeLouise, Lisa A

Published In Sci Rep, (2019 Mar 25)

Abstract: Amorphous silicon dioxide nanoparticles (SiNPs) are ubiquitous, and they are currently found in cosmetics, drugs, and foods. Biomedical research is also focused on using these nanoparticles as drug delivery and bio-sensing platforms. Due to the high potential for skin exposure to SiNPs, research into the effect of topical exposure on both healthy and inflammatory skin models is warranted. While we observe only minimal effects of SiNPs on healthy mouse skin, there is an immunomodulatory effect of these NPs in a model of allergic contact dermatitis. The effect appears to be mediated partly by keratinocytes and results in decreases in epidermal hyperplasia, inflammatory cytokine release, immune cell infiltration, and a subsequent reduction in skin swelling. Additional research is required to further our mechanistic understanding and to validate the extent of this immunomodulatory effect in human subjects in order to assess the potential prophylactic use of SiNPs for treating allergic skin conditions.

PubMed ID: 30911099 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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