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Title: Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation.

Authors: Ammitzbøll, Cecilie; Börnsen, Lars; Petersen, Eva Rosa; Oturai, Annette Bang; Søndergaard, Helle Bach; Grandjean, Philippe; Sellebjerg, Finn

Published In J Neuroimmunol, (2019 05 15)

Abstract: Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

PubMed ID: 30852181 Exiting the NIEHS site

MeSH Terms: Adult; Alkanesulfonic Acids/blood*; Alkanesulfonic Acids/immunology*; Alkanesulfonic Acids/toxicity; Cohort Studies; Cross-Sectional Studies; Female; Fluorocarbons/blood*; Fluorocarbons/immunology*; Fluorocarbons/toxicity; Humans; Immunity, Cellular/drug effects; Immunity, Cellular/immunology*; Male; Middle Aged; Multiple Sclerosis/blood*; Multiple Sclerosis/diagnosis; Multiple Sclerosis/immunology*; Risk Factors

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