Title: Nanoparticulate matter exposure results in neuroinflammatory changes in the corpus callosum.

Authors: Babadjouni, Robin; Patel, Arati; Liu, Qinghai; Shkirkova, Kristina; Lamorie-Foote, Krista; Connor, Michelle; Hodis, Drew M; Cheng, Hank; Sioutas, Constantinos; Morgan, Todd E; Finch, Caleb E; Mack, William J

Published In PLoS One, (2018)

Abstract: Epidemiological studies have established an association between air pollution particulate matter exposure (PM2.5) and neurocognitive decline. Experimental data suggest that microglia play an essential role in air pollution PM-induced neuroinflammation and oxidative stress. This study examined the effect of nano-sized particulate matter (nPM) on complement C5 deposition and microglial activation in the corpus callosum of mice (C57BL/6J males). nPM was collected in an urban Los Angeles region impacted by traffic emissions. Mice were exposed to 10 weeks of re-aerosolized nPM or filtered air for a cumulative 150 hours. nPM-exposed mice exhibited reactive microglia and 2-fold increased local deposition of complement C5/ C5α proteins and complement component C5a receptor 1 (CD88) in the corpus callosum. However, serum C5 levels did not differ between nPM and filtered air cohorts. These findings demonstrate white matter C5 deposition and microglial activation secondary to nPM exposure. The C5 upregulation appears to be localized to the brain.

PubMed ID: 30395590

MeSH Terms: Air Pollution/adverse effects*; Animals; Complement C5/genetics*; Corpus Callosum/drug effects; Corpus Callosum/pathology; Humans; Inflammation/chemically induced; Inflammation/genetics; Inflammation/physiopathology*; Mice; Microglia/drug effects; Microglia/metabolism; Nanoparticles/adverse effects; Neurocognitive Disorders/chemically induced; Neurocognitive Disorders/genetics; Neurocognitive Disorders/physiopathology*; Oxidative Stress/drug effects; Particulate Matter/adverse effects