Title: Successful Whole Genome Sequencing-guided Treatment of Mycoplasma hominis Ventriculitis in a Preterm Infant.
Authors: Scaggs Huang, Felicia A; Mortensen, Joel; Skoch, Jesse; Andersen, Heidi; Staat, Mary Allen; Schaffzin, Joshua K; Haslam, David B
Published In Pediatr Infect Dis J, (2019 07)
Abstract: We report a case of Mycoplasma hominis ventriculitis in a preterm neonate that was successfully identified with 16S ribosomal RNA sequencing and whole genome sequencing after failure to detect the pathogen with conventional diagnostic methods. The infant required doxycycline with subsequent clearance of the infection and no evidence of drug toxicity.
PubMed ID: 30985508
MeSH Terms: Adult; Anti-Bacterial Agents/administration & dosage*; Cerebral Ventriculitis/diagnosis*; Cerebral Ventriculitis/drug therapy*; Cerebral Ventriculitis/microbiology; Cerebral Ventriculitis/pathology; Cluster Analysis; DNA, Bacterial/chemistry; DNA, Bacterial/genetics; DNA, Ribosomal/chemistry; DNA, Ribosomal/genetics; Doxycycline/administration & dosage*; Female; Humans; Infant, Newborn; Infant, Premature; Male; Mycoplasma Infections/diagnosis*; Mycoplasma Infections/drug therapy*; Mycoplasma Infections/microbiology; Mycoplasma Infections/pathology; Mycoplasma hominis/classification; Mycoplasma hominis/genetics; Mycoplasma hominis/isolation & purification*; Phylogeny; RNA, Ribosomal, 16S/genetics; Sequence Analysis, DNA; Treatment Outcome; Whole Genome Sequencing