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Title: Metabolomics of neonatal blood spots reveal distinct phenotypes of pediatric acute lymphoblastic leukemia and potential effects of early-life nutrition.

Authors: Petrick, Lauren M; Schiffman, Courtney; Edmands, William M B; Yano, Yukiko; Perttula, Kelsi; Whitehead, Todd; Metayer, Catherine; Wheelock, Craig E; Arora, Manish; Grigoryan, Hasmik; Carlsson, Henrik; Dudoit, Sandrine; Rappaport, Stephen M

Published In Cancer Lett, (2019 Jun 28)

Abstract: Early-life exposures are believed to influence the incidence of pediatric acute lymphoblastic leukemia (ALL). Archived neonatal blood spots (NBS), collected within the first days of life, offer a means to investigate small molecules that reflect early-life exposures. Using untargeted metabolomics, we compared abundances of small-molecule features in extracts of NBS punches from 332 children that later developed ALL and 324 healthy controls. Subjects were stratified by early (1-5 y) and late (6-14 y) diagnosis. Mutually-exclusive sets of metabolic features - representing putative lipids and fatty acids - were associated with ALL, including 9 and 19 metabolites in the early- and late-diagnosis groups, respectively. In the late-diagnosis group, a prominent cluster of features with apparent 18:2 fatty-acid chains suggested that newborn exposure to the essential nutrient, linoleic acid, increased ALL risk. Interestingly, abundances of these putative 18:2 lipids were greater in infants who were fed formula rather than breast milk (colostrum) and increased with the mother's pre-pregnancy body mass index. These results suggest possible etiologic roles of newborn nutrition in late-diagnosis ALL.

PubMed ID: 30904619 Exiting the NIEHS site

MeSH Terms: Adolescent; Age Factors; Biomarkers/blood; Bottle Feeding; Breast Feeding; California/epidemiology; Child; Child, Preschool; Dried Blood Spot Testing*; Energy Metabolism*; Female; Humans; Incidence; Infant; Infant Formula; Infant Nutritional Physiological Phenomena*; Infant, Newborn; Lipids/blood*; Male; Metabolomics*; Neonatal Screening/methods*; Nutritional Status*; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology*; Precursor Cell Lymphoblastic Leukemia-Lymphoma/prevention & control; Protective Factors; Risk Assessment; Risk Factors

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