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Publication Detail

Title: Impact of Pubertal Maturation and Chronologic Age on Sex Steroids in Peripubertal Girls.

Authors: Biro, Frank M; Huang, Bin; Chandler, Donald Walt; Fassler, Cecily L; Pinney, Susan M

Published In J Clin Endocrinol Metab, (2019 07 01)

Abstract: There is a 4- to 5-year variation in age of breast maturation in girls.To examine longitudinal changes in sex hormone values relative to chronologic age and time relative to breast maturation.Longitudinal observational study into which girls were recruited at 6 to 7 years of age and followed up every 6 months.Maturation status, chronologic age, race, and fasting blood specimen data were obtained. Hormones were analyzed at 6-month intervals between 2 years before and 1 year after breast maturation, using HPLC tandem mass spectroscopy.Estradiol and estrone levels correlated with chronologic age (R = 0.350 and 0.444, respectively); time was correlated relative to breast maturation (R = 0.222 and 0.323, respectively; all correlations, P < 0.0001). In generalized estimating equation (GEE) models, chronologic age and time relative to pubertal onset were significantly associated with serum estradiol, with similar results for estrone. Local estimated scatterplot smoothing for estradiol and estrone, by chronologic age, demonstrated differences between black and white girls, especially between 8.5 and 11 years of age, but not by race in time relative to breast maturation. Testosterone level was correlated to chronologic age (R = 0.362) and time relative to breast maturation (R = 0.259); in the GEE model, only chronologic age was significant.Chronologic age as well as time relative to onset of puberty provided unique information regarding estradiol and estrone concentrations in peripubertal girls. Serum estrogen concentrations should be evaluated with reference to chronologic age and race.

PubMed ID: 30882864 Exiting the NIEHS site

MeSH Terms: African Americans; Age Factors; Breast/growth & development*; Child; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate/metabolism; Estradiol/metabolism*; Estrone/metabolism*; European Continental Ancestry Group; Female; Hispanic Americans; Humans; Longitudinal Studies; Puberty/ethnology; Puberty/metabolism*; Puberty/physiology; Sexual Maturation/physiology; Tandem Mass Spectrometry; Testosterone/metabolism

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