Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Transcriptional responses to DNA damage.

Authors: Silva, Erica; Ideker, Trey

Published In DNA Repair (Amst), (2019 07)

Abstract: In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review differences in observed transcriptional responses as a function of cell cycle stage and emphasize the importance of experimental design in these transcriptional response studies. We additionally consider topics including structural challenges in the transcriptional response to DNA damage as well as the connection between transcription and protein abundance.

PubMed ID: 31102970 Exiting the NIEHS site

MeSH Terms: Animals; Cell Cycle; DNA Damage*; Humans; Stress, Physiological/genetics; Transcription, Genetic*; Yeasts/genetics

Back
to Top