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Publication Detail

Title: Role of AHR in the control of GBM-associated myeloid cells.

Authors: Gabriely, Galina; Quintana, Francisco J

Published In Semin Cancer Biol, (2020 08)

Abstract: Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and modulate myeloid cells. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor implicated in the regulation of myeloid cells. In this review, we will summarize current knowledge on the AHR role in the control of myeloid cells and its impact on GBM pathogenesis.

PubMed ID: 31128300 Exiting the NIEHS site

MeSH Terms: Animals; Brain Neoplasms/immunology; Brain Neoplasms/metabolism; Brain Neoplasms/pathology*; Glioblastoma/immunology; Glioblastoma/metabolism; Glioblastoma/pathology*; Humans; Myeloid Cells/immunology*; Receptors, Aryl Hydrocarbon/metabolism*; Signal Transduction

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