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National Institute of Environmental Health Sciences

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Publication Detail

Title: Effects of surface functional groups on the formation of nanoparticle-protein corona.

Authors: Podila, R; Chen, R; Ke, P C; Brown, J M; Rao, A M

Published In Appl Phys Lett, (2012 Dec 24)

Abstract: Herein, we examined the dependence of protein adsorption on the nanoparticle surface in the presence of functional groups. Our UV-visible spectrophotometry, transmission electron microscopy, infrared spectroscopy, and dynamic light scattering measurements evidently suggested that the functional groups play an important role in the formation of nanoparticle-protein corona. We found that uncoated and surfactant-free silver nanoparticles derived from a laser ablation process promoted a maximum protein (bovine serum albumin) coating due to increased changes in entropy. On the other hand, bovine serum albumin displayed a relatively lower affinity for electrostatically stabilized nanoparticles due to the constrained entropy changes.

PubMed ID: 23341687 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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