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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Impact of hypoxia on DNA repair and genome integrity.

Authors: Kaplan, Alanna R; Glazer, Peter M

Published In Mutagenesis, (2020 02 13)

Abstract: Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour biology, influencing cancer progression, the development of metastasis and patient outcome. Hypoxia also contributes to genomic instability and mutation frequency by inhibiting DNA repair pathways. This review summarises the diverse mechanisms by which hypoxia affects DNA repair, including suppression of homology-directed repair, mismatch repair and base excision repair. We also discuss the effects of hypoxia mimetics and agents that induce hypoxia on DNA repair, and we highlight areas of potential clinical relevance as well as future directions.

PubMed ID: 31282537 Exiting the NIEHS site

MeSH Terms: Cell Hypoxia; DNA Mismatch Repair; DNA Repair*; Gene Expression Regulation, Neoplastic; Genome; Genomic Instability; Humans; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasms/genetics*; Neoplasms/metabolism*; Neoplasms/pathology; Recombinational DNA Repair; Tumor Hypoxia/drug effects; Tumor Microenvironment/genetics

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