Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2.

Authors: Chen, Fangyi; Tang, Qi; Ma, Hang; Bian, Ke; Seeram, Navindra P; Li, Deyu

Published In Chem Res Toxicol, (2019 06 17)

Abstract: Hydrolyzable tannins are a class of polyphenolic compounds commonly found in natural products. In this work, we studied the in vitro inhibitory mechanism of six molecules in this class on ALKBH2, an Fe(II)/α-ketoglutarate-dependent DNA repair enzyme in the AlkB family. We determined the IC50 values of these compounds on the repair of 3-methylcytosine and 1-methyladenine, the prototypical substrates of ALKBH2. A structure-activity relationship was also observed between the strength of inhibition and the number of galloyl moieties in a molecule. In addition, we found that the inhibition by this class of polyphenolic compounds on ALKBH2 is through an iron-chelating mechanism.

PubMed ID: 31088072 Exiting the NIEHS site

MeSH Terms: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase/antagonists & inhibitors*; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase/metabolism; DNA Repair*; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology*; Humans; Hydrolyzable Tannins/chemistry; Hydrolyzable Tannins/pharmacology*; Iron Chelating Agents/chemistry; Iron Chelating Agents/pharmacology*; Molecular Structure; Structure-Activity Relationship

Back
to Top