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Publication Detail

Title: Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.

Authors: Labaki, Wassim W; Gu, Tian; Murray, Susan; Curtis, Jeffrey L; Yeomans, Larisa; Bowler, Russell P; Barr, R Graham; Comellas, Alejandro P; Hansel, Nadia N; Cooper, Christopher B; Barjaktarevic, Igor; Kanner, Richard E; Paine 3rd, Robert; McDonald, Merry-Lynn N; Krishnan, Jerry A; Peters, Stephen P; Woodruff, Prescott G; O'Neal, Wanda K; Diao, Wenqi; He, Bei; Martinez, Fernando J; Standiford, Theodore J; Stringer, Kathleen A; Han, MeiLan K

Published In Sci Rep, (2019 08 06)

Abstract: Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-smokers from the SPIROMICS cohort. We measured 27 serum metabolites, mostly amino acids, by 1H-nuclear magnetic resonance spectroscopy in 157 white ever-smokers with and without COPD. We tested the association between log-transformed metabolite concentrations and one-year incidence of respiratory exacerbations after adjusting for age, sex, current smoking, body mass index, diabetes, inhaled or oral corticosteroid use, study site and clinical predictors of exacerbations, including FEV1% predicted and history of exacerbations. The mean age of participants was 53.7 years and 58% had COPD. Lower concentrations of serum amino acids were independently associated with 1-year incidence of respiratory exacerbations, including tryptophan (β = -4.1, 95% CI [-7.0; -1.1], p = 0.007) and the branched-chain amino acids (leucine: β = -6.0, 95% CI [-9.5; -2.4], p = 0.001; isoleucine: β = -5.2, 95% CI [-8.6; -1.8], p = 0.003; valine: β = -4.1, 95% CI [-6.9; -1.4], p = 0.003). Tryptophan concentration was inversely associated with the blood neutrophil-to-lymphocyte ratio (p = 0.03) and the BODE index (p = 0.03). Reduced serum amino acid concentrations in ever-smokers with and without COPD are associated with an increased incidence of respiratory exacerbations.

PubMed ID: 31388056 Exiting the NIEHS site

MeSH Terms: Amino Acids/blood*; Female; Humans; Isoleucine/blood; Leucine/blood; Male; Metabolomics; Middle Aged; Patient Outcome Assessment; Proton Magnetic Resonance Spectroscopy; Pulmonary Disease, Chronic Obstructive/blood*; Smokers*; Tryptophan/blood; Valine/blood

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