Title: Role of CTCF in DNA damage response.
Authors: Tanwar, Vinay Singh; Jose, Cynthia C; Cuddapah, Suresh
Published In Mutat Res, (2019 Apr - Jun)
Abstract: CCCTC-binding factor (CTCF) is a highly conserved, ubiquitously expressed zinc finger protein. CTCF is a multifunctional protein, associated with a number of vital cellular processes such as transcriptional activation, repression, insulation, imprinting and genome organization. Emerging evidence indicates that CTCF is also involved in DNA damage response. In this review, we focus on the newly identified role of CTCF in facilitating DNA double-strand break repair. Due to the large number of cellular processes in which CTCF is involved, factors that functionally affect CTCF could have serious implications on genomic stability. It is becoming increasingly clear that exposure to environmental toxicants could have adverse effects on CTCF functions. Here we discuss the various ways that environmental toxicants could impact CTCF functions and the potential consequences on DNA damage response.
PubMed ID: 31395350
MeSH Terms: Animals; CCCTC-Binding Factor/genetics*; DNA Breaks, Double-Stranded; DNA Damage/genetics*; DNA Repair/genetics*; Genome/genetics; Genomic Instability/genetics; Humans