Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Cord Leptin is Associated with Neuropsychomotor Development in Childhood.

Authors: Karakosta, Polyxeni; Margetaki, Katerina; Fthenou, Eleni; Kampouri, Mariza; Kyriklaki, Andriani; Koutra, Katerina; Chalkiadaki, Georgia; Roumeliotaki, Theano; Vafeiadi, Marina; Kogevinas, Manolis; Mantzoros, Christos; Chatzi, Lida

Published In Obesity (Silver Spring), (2019 10)

Abstract: Leptin is critical for central nervous system development and maturation. This study aimed to evaluate the potential regulatory role of cord leptin in the neuropsychomotor development of children ages 18 months to 6 years.This study included 424 children from a prospective mother-child cohort (Rhea Study; Crete, Greece) with available cord leptin levels and data on neurodevelopmental outcomes at 18 months (Bayley Scales of Infant and Toddler Development, Third Edition), 4 years (McCarthy Scales of Children's Abilities), and 6 years (Raven's Coloured Progressive Matrices and Trail Making Test). Multivariable linear regression models were used to explore the associations.Each 10-ng/mL increase in the cord leptin level was associated with increased scores on the gross motor scale at 18 months (β coefficient: 3.8; 95% CI: 0.0-7.5), with decreased scores in the general cognitive performance (β coefficient: -3.0; 95% CI: -5.5 to -0.4), perceptual performance (β coefficient: -3.4; 95% CI: -6.0 to -9.9), working memory (β coefficient: -3.1; 95% CI: -5.7 to -0.4), executive function (β coefficient -3.1; 95% CI: -5.7 to -0.5), and functions of the posterior cortex (β coefficient: -2.7; 95% CI: -5.2 to -0.1) scales at 4 years, and with a 3.7-unit decrease in the Raven's Coloured Progressive Matrices score at 6 years (β coefficient: -3.7; 95% CI: -6.9 to -0.5).Increased cord leptin levels are associated with enhanced gross motor development at 18 months but decreased cognitive performance in early and middle childhood.

PubMed ID: 31479200 Exiting the NIEHS site

MeSH Terms: Central Nervous System/growth & development*; Child; Child Development/physiology*; Child, Preschool; Cohort Studies; Female; Fetal Blood/chemistry*; Greece; Humans; Infant; Infant, Newborn; Intelligence Tests; Leptin/analysis; Leptin/blood*; Male; Memory, Short-Term/physiology; Prospective Studies; Psychomotor Disorders/blood; Psychomotor Disorders/diagnosis

Back
to Top