Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Astrocyte-mediated methylmercury neurotoxicity.

Authors: Shanker, Gouri; Syversen, Tore; Aschner, Michael

Published In Biol Trace Elem Res, (2003 Oct)

Abstract: Methylmercury (MeHg) is a potent neurotoxicant. Any source of environmental mercury represents a potential risk for human MeHg poisoning, because the methylation of inorganic mercury to MeHg in waterways results ultimately in its accumulation in the sea food chain, which represents the most prevalent source for human consumption. A small amount of MeHg accumulates in the central nervous system (CNS), particularly in astrocytes. Astrocytic swelling, excitatory amino acid (EAA) release and uptake inhibition, as well as EAA transporter expression inhibition are known sequelae of MeHg exposure. Herein, we review the effect of MeHg on additional transport systems (for cystine and cysteine) as well as arachidonic acid (AA) release and cytosolic phospholipase A2 (cPLA2) regulation and attempt to integrate the effects of MeHg in astrocytes within a mechanistic hypothesis that explains the inability of these cells to maintain control of the proper milieu of the extracellular fluid and, in turn, leads to neuronal demise.

PubMed ID: 14555794 Exiting the NIEHS site

MeSH Terms: Animals; Arachidonic Acid/biosynthesis; Astrocytes/drug effects*; Astrocytes/metabolism; Astrocytes/pathology*; Cysteine/antagonists & inhibitors; Cysteine/metabolism; Cystine/antagonists & inhibitors; Cystine/metabolism; Enzyme Activation/drug effects; Glutathione/metabolism; Humans; Mercury Poisoning, Nervous System/metabolism*; Mercury Poisoning, Nervous System/pathology; Methylmercury Compounds/toxicity*; Phospholipases A/metabolism; Phospholipases A2

Back
to Top