Title: New Insights on the Role of Manganese in Alzheimer's Disease and Parkinson's Disease.
Authors: Martins Jr, Airton Cunha; Morcillo, Patricia; Ijomone, Omamuyovwi Meashack; Venkataramani, Vivek; Harrison, Fiona Edith; Lee, Eunsook; Bowman, Aaron Blaine; Aschner, Michael
Published In Int J Environ Res Public Health, (2019 09 22)
Abstract: Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer's disease (AD) and Parkinson's disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.
PubMed ID: 31546716
MeSH Terms: Alzheimer Disease/chemically induced*; Animals; Humans; Mammals; Manganese/toxicity*; Neurotoxins/toxicity*; Parkinson Disease/etiology*