Title: Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure.
Authors: Hena, Kerry M; Murphy, Scarlett; Zhang, Yian; Shao, Yongzhao; Kazeros, Angeliki; Reibman, Joan
Published In Int J Environ Res Public Health, (2019 04 10)
Abstract: Background: Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods: Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results: Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had ≥ Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33/87 (38%) with a diversity of organs involved. Conclusions: WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution.
PubMed ID: 30974916
MeSH Terms: Adult; Dust; Environmental Exposure/adverse effects*; Female; Humans; Lung Diseases/diagnosis*; Lung Diseases/physiopathology; Lung/physiopathology; Male; Middle Aged; Respiratory Function Tests; Sarcoidosis/diagnosis*; Sarcoidosis/physiopathology; September 11 Terrorist Attacks*